NET-PD LS-1 Creatine in Parkinson's Disease

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Parkinson's Disease

In brief

The purpose of this trial is to determine if the nutritional supplement creatine slows the progression of Parkinson's disease over time.

Key facts

Study ID

NCT00449865

Run by

University of Rochester

People needed

1741

Starts

2007-03-01

Expected to finish

2014-05-01

Last updated by the study team

2015-04-02

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Willing and able to give informed consent and willing to commit to long-term follow-up
• PD (asymmetric features including slowness (bradykinesia) plus resting tremor and/or rigidity) within 5 years of diagnosis
• Treated/responsive to dopaminergic therapy (dopamine agonists or levodopa) for at least 90 days, but not more than 2 years.

You may not qualify if…

• Use of creatine 14 days prior to baseline or during the study
• History of known hypersensitivity or intolerability to creatine
• Any unstable or clinically significant condition that would impair the subject's ability to comply with long term study follow-up
• Other know or suspected causes of parkinsonism (e.g. metabolic, drug induced, etc.), or any significant features suggestive of a diagnosis of atypical parkinsonism.

Where it is running

• University Of Alabama, Birmingham, 350 Sparks Center, 1720 7th Avenue South — Birmingham, Alabama, United States
• Barrow Neurological Clinics At, St Joseph's Hospital & Medical Center, 500 West Thomas Road Suite 720, — Phoenix, Arizona, United States
• Parkinson's & Movement Disorder Institute, 9940 Talbert Avenue, Suite 204, — Fountain Valley, California, United States
• University Of Southern California, Healthcare Consultation Building II, 1520 San Pablo Street Suite 3000 — Los Angeles, California, United States
• University Of California San Francisco, Parkinson's Disease Clinic And Research Cen, 505 Parnassus Avenue M-798 — San Francisco, California, United States
• The Parkinson's Institute, 675 Almanor Avenue — Sunnyvale, California, United States
• University Of Colorado Health Sciences Ctr, 4200 East 9th Avenue Campus Box C238, Department Of Clinical Pharmacy — Denver, Colorado, United States
• Neurodegenerative Disorders, 60 Temple Street Suite 8b — New Haven, Connecticut, United States
• VA Medical Center, 1601 Southwest Archer Road, Neurology Service (151) — Gainesville, Florida, United States
• University Of Florida, Mcknight Brain Institute, 100 South Newell Drive Room L3-100 — Gainesville, Florida, United States
• University Of Florida Jacksonville, 580 West 8th Street, Tower 1 8th Floor, — Jacksonville, Florida, United States
• University Of Miami, 1501 North West 9th Avenue Second Floor, Department Of Neurology D4-5 — Miami, Florida, United States
• University Of South Florida, Movement Disorders Center, 5 Tampa General Circle Suite 410 — Tampa, Florida, United States
• Emory University, Wesley Woods Health Center, 1841 Clifton Road NE Room 328 — Atlanta, Georgia, United States
• Medical College Of Georgia, Movement Disorders Clinic, 1429 Harper Street HF 1121 — Augusta, Georgia, United States
• Pacific Health Research Institute, 405 North Kuakini Street, Suite 1011, — Honolulu, Hawaii, United States
• Northwestern University, 710 North Lake Shore Drive — Chicago, Illinois, United States
• Rush University Medical Center, Department Of Neurological Sciences, 1725 West Harrison Suite 755, — Chicago, Illinois, United States
• Evanston Northwestern Healthcare, Department Of Neurology, 2100 Pfingsten Road Suite B110 — Glenview, Illinois, United States
• Southern Illinois University School Of Medicine, PO Box 19645 — Springfield, Illinois, United States
• Indiana University School Of Medicine, Outpatient Clinical Research Facility, 535 Barnhill Drive Room #150 — Indianapolis, Indiana, United States
• University Of Kansas Medical Center, 3599 Rainbow Blvd, Department Of Neurology Mail Stop # 2012 — Kansas City, Kansas, United States
• University Of Kentucky Clinical Research, C201 Kentucky Clinic, 740 South Limestone Street — Lexington, Kentucky, United States
• Ochsner Clinic Foundation, 1514 Jefferson Highway, Dept. Of Neurology 7th Floor — New Orleans, Louisiana, United States
• LSU Health Science Center Shreveport, 1501 Kings Highway, Room 3-436 — Shreveport, Louisiana, United States

Full record on ClinicalTrials.gov

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