Cigarette Smoke and Susceptibility to Influenza Infection
Completed
Conditions studied: Healthy
In brief
This study will be a descriptive comparison of the effects of live attenuated influenza virus (FluMist) on nasal inflammation and oxidative stress in healthy young adults who are not exposed to smoke vs smokers. It is hypothesized that passive exposure to second-hand smoke (SHS) results in increased susceptibility to the effects of influenza virus in nasal epithelium in humans and that these effects are mediated by SHS-induced oxidative stress
Key facts
- Study ID
- NCT00448617
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 138
- Starts
- 2006-07-01
- Expected to finish
- 2011-09-01
- Last updated by the study team
- 2015-05-29
Who can join
Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- age 18-35 years
- healthy nonsmoking who are rarely exposed to SHS OR smokers
You may not qualify if…
- pregnancy or nursing;
- history of egg allergy;
- aspirin therapy;
- asthma;
- immunodeficiency (HIV or other);
- on immunosuppressive drugs including corticosteroids;
- history of Guillain-Barre Syndrome;
- any chronic medical condition;
- febrile and/or respiratory illness within past 3 weeks prior to entry into study;
- prospective subjects with high baseline antibody titers against influenza will be excluded because they may be less likely to develop viral replication with LAIV.
Where it is running
- UNC Center for Environmental Medicine, Asthma and Lung Biology — Chapel Hill, North Carolina, United States
Full record on ClinicalTrials.gov
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