Bracing in Adolescent Idiopathic Scoliosis Trial (BrAIST)

Stopped early · Not applicable

Conditions studied: Adolescent Idiopathic Scoliosis

In brief

Adolescent idiopathic scoliosis (AIS) is a structural curve of the spine with no clear underlying cause. Bracing is currently the standard of care for preventing curve progression and treating AIS. However, the effectiveness of bracing remains unclear. The purpose of this study is to compare the risk of curve progression in adolescents with AIS who wear a brace versus those who do not and to determine whether there are reliable factors that can predict the usefulness of bracing for a particular individual with AIS.

Key facts

Study ID

NCT00448448

Run by

Stuart L. Weinstein, MD

People needed

383

Starts

2007-02-01

Expected to finish

2013-09-01

Last updated by the study team

2026-03-02

Who can join

Age: 10 and older, up to 15. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of AIS
• Skeletally immature (Risser grade 0, 1, or 2)
• Pre-menarchal or post-menarchal by no more than 1 year
• Primary Cobb angle between 20 and 40 degrees
• Curve apex caudal to T7 vertebrae
• Physical and mental ability to adhere to bracing protocol
• Ability to read and understand English, Spanish, or French
• Documented insurance coverage and/or personal willingness to pay for treatment

You may not qualify if…

• Diagnosis of other musculoskeletal or developmental illness that might be responsible for the spinal curvature
• History of previous surgical or orthotic treatment for AIS

Where it is running

• Children's Hospital Central California — Madera, California, United States
• Shriners Hospital of Northern California — Sacramento, California, United States
• Rady Childrens Hospital — San Diego, California, United States
• Alfred I. duPont Hospital for Children and Nemours Children's Clinic — Wilmington, Delaware, United States
• Children's Healthcare of Atlanta — Atlanta, Georgia, United States
• Shriner's Hospital for Children — Chicago, Illinois, United States
• University of Iowa Children's Hospital — Iowa City, Iowa, United States
• Shriners Hospitals for Children - Lexington — Lexington, Kentucky, United States
• Children's Hospital Boston — Boston, Massachusetts, United States
• Shriners Hospitals for Children - Minneapolis — Minneapolis, Minnesota, United States
• Children's Mercy Hospitals and Clinics. — Kansas City, Missouri, United States
• St. Louis Children's Hospital — St Louis, Missouri, United States
• Shriners Hospitals for Children - St. Louis — St Louis, Missouri, United States
• Carrie Tingley Hospital — Albuquerque, New Mexico, United States
• Hospital for Special Surgery — New York, New York, United States
• University of Rochester Medical Center — Rochester, New York, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States
• Shriners Hospitals for Children - Salt Lake City — Salt Lake City, Utah, United States
• University of Virginia Health System — Charlottesville, Virginia, United States
• Children's Hospital and Regional Medical Center — Seattle, Washington, United States
• BC Children's Hospital — Vancouver, British Columbia, Canada
• Hospital for Sick Children — Toronto, Ontario, Canada
• Shriner's Hospital for Children — Montreal, Quebec, Canada

Full record on ClinicalTrials.gov

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