A Study of Encapsulated Cell Technology (ECT) Implant for Participants With Early Stage Retinitis Pigmentosa
Completed · Phase 2
Conditions studied: Retinitis Pigmentosa
In brief
The purpose of this study is to look at the safety and effectiveness of CNTF implants on vision in persons with retinitis pigmentosa, Usher type II \& III, and Choroideremia. This research is being done because there are no effective therapies for people with these retinal degenerations. They are genetic disorders that affect one's ability to see at night, and later cause tunnel vision and loss of central vision. Retinal degenerations affect the retina, a light sensitive layer of cells in the back of the eye. Slowly over time, these cells die and cause permanent loss of vision. The implant is a small capsule that contains human retinal pigment epithelium cells. These cells have been given the ability to make CNTF and release it through the capsule membrane into the surrounding fluid. In this study, two different CNTF dose levels will be used: a high dose and a low dose in one eye, as well as a sham (or placebo) surgery in the other eye.
Key facts
- Study ID
- NCT00447980
- Run by
- Neurotech Pharmaceuticals
- People needed
- 73
- Starts
- 2007-01-22
- Expected to finish
- 2010-04-19
- Last updated by the study team
- 2025-05-01
Who can join
Age: 18 and older, up to 64. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Retina-Vitreous Associates Medical Group — Beverly Hills, California, United States
- University of Califoria, Davis — Sacramento, California, United States
- University of California, San Francisco — San Francisco, California, United States
- Bascom Palmer Eye Insitute — Miami, Florida, United States
- Kellogg Eye Center — Ann Arbor, Michigan, United States
- University of Minnesota — Minneapolis, Minnesota, United States
- NY University Medical Center — New York, New York, United States
- Casey Eye Institue — Portland, Oregon, United States
- The Hamilton Eye Institute — Memphis, Tennessee, United States
- Retina Foundation of Southwest — Dallas, Texas, United States
- University of Utah — Salt Lake City, Utah, United States
- The University of Utah - John A. Moran Eye Center — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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