A Study of an Encapsulated Cell Technology (ECT) Implant for Patients With Atrophic Macular Degeneration
Completed · Phase 2 · Has a placebo group
Conditions studied: Nonexudative Age-Related Macular Degeneration, Unspecified Eye, Intermediate Dry Stage
In brief
The purpose of this study is to look at the safety and effectiveness of CNTF implants on vision in participants with atrophic macular degeneration. This research is being done because there are no effective therapies for people with atrophic macular degeneration. Age-related macular degeneration (AMD) is a condition that affects the macula, the central part of the retina that we use for seeing details. There are two types of AMD, one is the wet type in which new blood vessels grow, also known as choroidal neovascularization (CNV), but the other is the dry type in which the healthy cells die, and that is the target of this study. This is called atrophic macular degeneration. The implant is a small capsule that contains human retinal pigment epithelium cells. These cells have been given the ability to make CNTF and release it through the capsule membrane into the surrounding fluid. In this study, two different CNTF dose levels will be used: a high dose and a low dose, as well as a sham surgery (or placebo) group.
Key facts
- Study ID
- NCT00447954
- Run by
- Neurotech Pharmaceuticals
- People needed
- 53
- Starts
- 2007-01-05
- Expected to finish
- 2009-05-11
- Last updated by the study team
- 2025-03-28
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Retina-Vitreous Associates Medical Group — Beverly Hills, California, United States
- Retina Group of Florida — Hollywood, Florida, United States
- Bascom Palmer Eye Institute — Miami, Florida, United States
- Ophthalmic Consultants of Boston — Boston, Massachusetts, United States
- Beaumont Eye Institute — Royal Oak, Michigan, United States
- Retina Foundation of Southwest — Dallas, Texas, United States
- Vitreoretinal Consultants — Houston, Texas, United States
- University of Utah — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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