Study Evaluating MOA-728 in Subjects on Stable Methadone Maintenance

Completed · Phase 1

Conditions studied: Methadone-maintenance Subjects

In brief

This is a study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of MOA-728 in subjects on stable methadone maintenance.

Key facts

Study ID

NCT00447811

Run by

Bausch Health Americas, Inc.

Starts

2007-03-01

Expected to finish

2007-05-01

Last updated by the study team

2019-11-25

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• History of methadone treatment for at least 1 month before day -1 at a dose of ≥ 30 mg/day, and a positive drug test result for methadone.
• Healthy as determined by the investigator on the basis of screening evaluations.

You may not qualify if…

• Allergy to opioids (eg, codeine, morphine, or oxymorphone) or opioid antagonists (eg, naloxone or naltrexone).
• Any significant cardiovascular, hepatic, renal, respiratory, gastrointestinal, endocrine, immunologic, dermatologic, hematologic, neurologic, or psychiatric disease.

Where it is running

• Study site — Willingboro, New Jersey, United States

Full record on ClinicalTrials.gov

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