S0636: Erlotinib and Bevacizumab in Never-Smokers With Stage IIIB or Stage IV Primary Non-Small Cell Lung Cancer
Completed · Phase 2
Conditions studied: Lung Cancer
In brief
RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab also may stop the growth of non-small cell lung cancer by blocking blood flow to the tumor. Giving erlotinib together with bevacizumab may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving erlotinib together with bevacizumab works in treating patients with stage IIIB or stage IV primary non-small cell lung cancer who have never smoked.
Key facts
- Study ID
- NCT00445848
- Run by
- SWOG Cancer Research Network
- People needed
- 89
- Starts
- 2007-07-01
- Expected to finish
- 2014-01-01
- Last updated by the study team
- 2020-03-05
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Alta Bates Summit Comprehensive Cancer Center — Berkeley, California, United States
- Peninsula Medical Center — Burlingame, California, United States
- Kaiser Permanente - Fremont — Fremont, California, United States
- Marin Cancer Institute at Marin General Hospital — Greenbrae, California, United States
- Kaiser Permanente Medical Center - Hayward — Hayward, California, United States
- Tibotec Therapeutics - Division of Ortho Biotech Products, LP — Marysville, California, United States
- Kaiser Permanente Medical Center - Oakland — Oakland, California, United States
- Valley Medical Oncology Consultants - Pleasanton — Pleasanton, California, United States
- Kaiser Permanente Medical Center - Redwood City — Redwood City, California, United States
- Kaiser Permanente Medical Center - Richmond — Richmond, California, United States
- Kaiser Permanente Medical Center - Roseville — Roseville, California, United States
- University of California Davis Cancer Center — Sacramento, California, United States
- South Sacramento Kaiser-Permanente Medical Center — Sacramento, California, United States
- Kaiser Permanente Medical Center - Sacramento — Sacramento, California, United States
- Kaiser Permanente Medical Center - San Francisco Geary Campus — San Francisco, California, United States
- California Pacific Medical Center - California Campus — San Francisco, California, United States
- Kaiser Permanente Medical Center - Santa Teresa — San Jose, California, United States
- Kaiser Foundation Hospital - San Rafael — San Rafael, California, United States
- Sutter Health - Western Division Cancer Research Group — San Rafael, California, United States
- Kaiser Permanente Medical Center - Santa Clara Kiely Campus — Santa Clara, California, United States
- Kaiser Permanente Medical Center - Santa Rosa — Santa Rosa, California, United States
- Kaiser Permanente Medical Center - South San Francisco — South San Francisco, California, United States
- Kaiser Permanente Medical Facility - Stockton — Stockton, California, United States
- Tahoe Forest Cancer Center — Truckee, California, United States
- Kaiser Permanente - Deer Valley — Antioch, California, United States
Full record on ClinicalTrials.gov
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