Effect of Acid Reflux on Respiratory Physiology During Exercise in Athletes With GER-Response to Acid Suppression

Stopped early · Phase 1 · Has a placebo group

Conditions studied: Exercise Triggered Asthma, Gastroesophageal Reflux

In brief

We propose that acid reflux affects respiratory dynamics (breathing) in patients who are exercising and that athletes improve their exercise capacity with acid suppression therapy. It is our intent to determine whether treatment of GER with strong acid suppression may alleviate symptoms, improve exercise capacity, and improve quality of life.

Key facts

Study ID: NCT00444236
Run by: University of Utah
People needed: 31
Starts: 2007-04-01
Expected to finish: 2009-09-01
Last updated by the study team: 2016-01-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

We plan to take athletes (cyclists) with GER (heartburn symptoms on a daily-weekly basis which are either improved by a trial of acid suppression or objectively documented via pH/endoscopic testing- this may include during exercise) who experience one or more of the following symptoms during exercise, limiting their perceived ability to exercise to full capacity:
choking
cough
wheezing
shortness of breath
chest tightness during exercise
Athletes will be defined as persons who exercise on a routine basis (at least 3 times a week on average) for at least the past 6 months.
Subjects must be at least 18 years old.

You may not qualify if…

Pregnancy
Age less than 18 years or greater than 65 years
Abnormal methacholine challenge tests will not exclude one from enrollment as (has been documented in a prior study) often patients with GER will have heightened bronchial reactivity.

Where it is running

University of Utah Health Sciences Center — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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