Transfusion-Associated Microchimerism in Previously Injured Individuals Who Received a Blood Transfusion

Stopped early

Conditions studied: Chimerism, Blood Transfusion, Wounds and Injuries

In brief

Blood transfusions are frequently necessary in situations in which there is a large amount of blood loss. In some individuals who receive a blood transfusion, white blood cells from the donor's blood may remain in the body for years, a condition known as microchimerism. This study will evaluate the occurrence of microchimerism among the following three groups of individuals who previously received transfusions: 1) individuals with traumatic injuries; 2) individuals with burn injuries; and 3) individuals who underwent elective orthopedic operations.

Key facts

Study ID

NCT00441779

Run by

National Heart, Lung, and Blood Institute (NHLBI)

People needed

59

Starts

2008-08-01

Expected to finish

2011-10-01

Last updated by the study team

2016-07-12

Who can join

Age: 8 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Hospitalized for traumatic injury, thermal injury, or an elective orthopedic surgical procedure from 2000 to 2003 at the University of California at Davis Medical Center
• Received at least 1 unit of transfused red blood cells

You may not qualify if…

• Currently incarcerated
• Inadequate decision-making capacity of the participant and no available surrogate decision-maker
• Prior bone marrow or solid organ transplantation
• Prior blood transfusion other than at the time of hospitalization
• Any history of an autoimmune disorder prior to hospitalization

Where it is running

• University of California, Davis, Medical Center — Sacramento, California, United States

Full record on ClinicalTrials.gov

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