Effects of N-acetylcysteine on Muscle Fatigue in Hemodialysis

Completed · Phase 1 · Has a placebo group

Conditions studied: End-Stage Renal Disease, Dialysis, Hemodialysis

In brief

The purposes of the study are to determine whether oxidative stress causes the muscle of dialysis patients to tire more quickly than muscle of people without kidney disease and to determine whether treatment with N-acetylcysteine, an antioxidant, can improve muscle endurance.

Key facts

Study ID

NCT00440869

Run by

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

People needed

30

Starts

2007-03-01

Expected to finish

2009-12-01

Last updated by the study team

2010-03-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• age greater than 18 years
• undergoing hemodialysis for 3 months or more or healthy control without kidney disease

You may not qualify if…

• inability to give informed consent
• diagnosis of diabetes mellitus
• musculoskeletal contraindication to exercise
• infection requiring intravenous antibiotics within 2 months
• hospitalization within 2 months
• ingestion of antioxidant supplements within one month
• requirement for systemic anticoagulation
• estimated GFR <60 ml/min/1.73 m2 for healthy controls

Where it is running

• San Francisco VA Medical Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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