The Effect Of A Controlled Daily Skin Care Regimen On Retinoic Acid Tolerance

Completed · Not applicable

Conditions studied: Sun-Damaged Skin, Retinoid Intolerance

In brief

Sun-damaged skin, caused by chronic exposure to ultraviolet (UV) light, is characterized by features such as wrinkling, uneven skin color, roughness and brown spots. An effective treatment for sun-damage that is commonly prescribed is topical retinoic acid (RA). However, the major drawback of topical RA use has been frequently observed irritation characterized by redness, dry skin and severe itching. In this study, we examine whether a daily skin care regimen comprised of an ultra mild cleanser and an effective moisturizer can help improve tolerance to RA treatment.

Key facts

Study ID

NCT00440024

Run by

University of Michigan

People needed

40

Starts

2007-02-01

Expected to finish

2009-11-01

Last updated by the study team

2020-03-13

Who can join

Age: 40 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Caucasians between the ages of 40 and 90 with moderate to severe sun-damage on the face who are generally healthy may participate.
• You must demonstrate a previous history of retinoid intolerance (established through prior history and the 2-week retinoid treatment phase of this study).
• Women of childbearing potential must agree to use an accepted form of birth control for the entire duration of the study.
• You must live within a reasonable driving distance of Ann Arbor, Michigan, and/or be able to attend all of the scheduled appointments during the study.

You may not qualify if…

• You may not have used any topical or systemic retinoids in the past 6 months.
• Women who are pregnant or nursing may not participate.
• If you have a history of non-melanoma skin cancer on the face in the past 5 years, you may not participate.
• If you have any history of malignant melanoma you may not participate.
• If you have any other skin condition or facial hair that will interfere with the study evaluations, you may not participate.
• If you have a known sensitivity to any of the ingredients in the study cream or Dove products, you may not participate.
• If you are currently on special daily skin care regimens that include cleansing with Dove, Olay, Aveeno or Cetaphil liquid facial cleansers and using facial moisturizers more than twice a day you may not participate.

Where it is running

• University of Michigan Department of Dermatology — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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