Safety/Efficacy of Valsartan/Hydrochlorothiazide Combination Compared to Hydrochlorothiazide in Obese Hypertensive Adults
Completed · Phase 4
Conditions studied: Hypertension
In brief
The purpose of this study is to compare the blood pressure lowering efficacy of valsartan/hydrochlorothiazide (HCTZ) compared to hydrochlorothiazide for the treatment of obese hypertensive (mean sitting systolic blood pressure \[MSSBP\] \>150 mmHg) patients.
Key facts
- Study ID
- NCT00439738
- Run by
- Novartis Pharmaceuticals
- People needed
- 412
- Starts
- 2006-12-01
- Last updated by the study team
- 2017-05-16
Who can join
Age: 40 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 40 years of age or older
- Moderate or severe high blood pressure defined as systolic blood pressure (the top number) greater than or equal to 150 mmHg and diastolic blood pressure (the bottom number) less then 110 mmHg
- Central (abdominal) obesity
You may not qualify if…
- Systolic blood pressure (the top number) greater than or equal to 180 mmHg and diastolic blood pressure (the bottom number) greater than or equal to 110 mmHg
- Currently taking more then 3 medications to treat high blood pressure
- Inability to stop all current blood pressure medications if any up to 4 weeks
- History of Type 1 or Type 2 diabetes
- History of stroke, mini-stroke (transient ischemic attack) or heart attack within the last 6 months
- History of or current diagnosis of congestive heart failure
- History of cancer within the past 5 years with the exception of localized basal cell carcinoma or squamous cell carcinoma
- Women who are pregnant or nursing
- Alcohol or drug abuse within the last 2 years
- Other protocol-defined inclusion/exclusion criteria may apply
Where it is running
- Terence T. Hart, MD — Muscle Shoals, Alabama, United States
- Westlake Medical Research — Westlake Village, California, United States
- Oklahoma Cardiovascular & Hypertension — Oklahoma City, Oklahoma, United States
- Northeast Tarrant Internal Medicine Assoc — Euless, Texas, United States
- Frandsen Family Medicine — Port Orchard, Washington, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.