Sibling Donor Peripheral Stem Cell Transplant or Sibling Donor Bone Marrow Transplant in Treating Patients With Hematologic Cancers or Other Diseases

Completed · Phase 3

Conditions studied: Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma, Myelodysplastic Syndromes, Secondary Myelofibrosis

In brief

RATIONALE: Giving chemotherapy before a donor peripheral stem cell transplant or bone marrow transplant using stem cells from a brother or sister that closely match the patient's stem cells, helps stop the growth of cancer or abnormal cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer or abnormal cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving colony-stimulating factors, such as G-CSF, to the donor helps the stem cells move from the bone marrow to the blood so they can be collected and stored. Giving methotrexate and cyclosporine before and after transplant may stop this from happening. It is not yet known whether a donor peripheral stem cell transplant is more effective than a donor bone marrow transplant in treating hematologic cancers or other diseases. PURPOSE: This randomized phase III trial is studying filgrastim-mobilized sibling donor peripheral stem cell transplant to see how well it works compared with sibling donor bone marrow transplant in treating patients with hematologic cancers or other diseases.

Key facts

Study ID

NCT00438958

Run by

The Canadian Blood and Marrow Transplant Group

People needed

230

Starts

2007-03-01

Last updated by the study team

2014-03-05

Who can join

Age: 16 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Fred Hutchinson Cancer Research Center — Seattle, Washington, United States
• Institute of Medical and Veterinary Science — Adelaide, South Australia, Australia
• Royal Melbourne Hospital — Parkville, Victoria, Australia
• Vancouver Hospital and Health Science Center — Vancouver, British Columbia, Canada
• CancerCare Manitoba — Winnipeg, Manitoba, Canada
• Cancer Care Nova Scotia — Halifax, Nova Scotia, Canada
• McMaster Children's Hospital at Hamilton Health Sciences — Hamilton, Ontario, Canada
• London Regional Cancer Program at London Health Sciences Centre — London, Ontario, Canada
• Ottawa Hospital Regional Cancer Centre - General Campus — Ottawa, Ontario, Canada
• Princess Margaret Hospital — Toronto, Ontario, Canada
• Maisonneuve-Rosemont Hospital — Montreal, Quebec, Canada
• Royal Victoria Hospital - Montreal — Montreal, Quebec, Canada
• Hopital de L'Enfant Jesus — Québec, Quebec, Canada
• Centre Hospitalier Universitaire de Quebec — Québec, Quebec, Canada
• Auckland City Hospital — Auckland, New Zealand
• King Faisal Specialist Hospital and Research Center — Riyadh, Saudi Arabia

Full record on ClinicalTrials.gov

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