Angiogenesis in Women With Angina Pectoris Who Are Not Candidates for Revascularization

Status unconfirmed · Phase 3 · Has a placebo group

Conditions studied: Angina Pectoris

In brief

The purpose of this study is to determine whether a one-time intracoronary infusion of Ad5FGF-4 is effective in reducing the time to onset myocardial ischemia as measured by exercise treadmill testing and improving myocardial blood flow as measured by SPECT imaging. Exercise capacity, angina functional class, patient symptoms and quality of life will also be evaluated to characterize the efficacy of Ad5FGF-4. Short-term and long-term safety of Ad5FGF-4 will also be evaluated.

Key facts

Study ID

NCT00438867

Run by

Cardium Therapeutics

People needed

300

Starts

2007-05-01

Last updated by the study team

2013-02-13

Who can join

Age: 18 and older, up to 75. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female patients 18-75 years of age inclusive
• Stable angina classified as CCS III or IV
• Receiving treatment with at least two classes of chronic anti-anginal medication, of which two are at the maximally tolerated dose
• Left ventricular ejection fraction (LVEF) of ≥30%
• Not a candidate for, or unlikely to benefit from standard revascularization procedures as verified by an independent cardiologist or cardiothoracic surgeon (not a study investigator) at each center
• Can undergo ETT using the modified Bruce protocol and;
• ECG changes diagnostic of myocardial ischemia occur during the first 10 minutes of exercise
• Variability of the time to onset of ECG changes diagnostic of myocardial ischemia is ≤25% or within 60 seconds if the time to onset of myocardial ischemia occurs within the first 4 minutes of exercise as determined by two consecutive screening treadmill tests
• Evidence of stress induced myocardial ischemia by adenosine SPECT, defined as a reversible perfusion defect size of ≥9%
• Willing and able to comply with the study requirements including long-term follow-up
• Provided written informed consent

You may not qualify if…

• Patients of childbearing potential (must be surgically sterile or post-menopausal)
• Patients for whom an immediate revascularization procedure is indicated (CABG surgery or PCI)
• Myocardial infarction within the past 3 months
• Unstable angina or hospitalization requiring intravenous anti-anginal therapy within the 14 days prior to the start of screening evaluations
• Congestive heart failure NYHA Class IV
• Electrocardiogram that precludes accurate assessment of exercise induced myocardial ischemia (e.g., left bundle branch block, Wolf-Parkinson-White syndrome, atrial fibrillation)
• Myocarditis or restrictive pericarditis
• Left main coronary stenosis ≥70% (unless the patient has a patent graft or collateral vessels supplying the left coronary circulation) or proximal stenoses ≥70% in all major coronary conduit vessels (coronary arteries and bypass grafts)
• Clinically significant aortic or mitral valvular heart disease
• Coronary ostial stenosis that precludes adequate catheter engagement in any target vessel
• Coronary artery to venous communications, which bypass the coronary capillary bed
• Untreated life-threatening ventricular arrhythmias
• CABG surgery within the past 6 months, unless those grafts are now occluded.
• Percutaneous transluminal angioplasty (PTCA) within the past 3 months, unless the dilated vessel(s) are now occluded
• Enhanced external counterpulsation (EECP) within 3 months prior to the start of screening evaluations
• Transmyocardial or percutaneous myocardial laser revascularization within the previous year
• Prior treatment with any cardiovascular gene or stem cell therapy.
• Any intercurrent illness that may interfere with their ability to perform a maximal ETT
• Any major organ disease that substantially impairs life expectancy.
• History of cancer, other than basal cell carcinoma, or patients with any laboratory or physical exam or diagnostic procedure finding suggestive of current malignancy
• Moderate to severe nonproliferative or proliferative retinopathy from any cause (ETDRS score >35), clinically significant macular edema, or previous panretinal photocoagulation therapy
• Heparin induced thrombocytopenia or history of idiopathic thrombocytopenic purpura or other medical condition causing thrombocytopenia
• SGPT level greater than 2.0 times the upper limit of the laboratory normal range
• Bilirubin level ≥2.0 mg/dL
• Serum creatinine ≥2.5 mg/dL

Where it is running

• University of Alabama — Birmingham, Alabama, United States
• Banner Heart Hospital — Phoenix, Arizona, United States
• Southwest Heart — Tucson, Arizona, United States
• Access Clinical Trials — Beverly Hills, California, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States
• Mission Internal Medical Group — Mission Viejo, California, United States
• UCSD Medical Center — San Diego, California, United States
• Aurora Denver Cardiology — Aurora, Colorado, United States
• South Denver Cardiology — Littleton, Colorado, United States
• Cardiovascular Research Institute — Washington D.C., District of Columbia, United States
• University of Florida — Gainesville, Florida, United States
• Florida Hospital — Orlando, Florida, United States
• St Joseph's Research Institute — Atlanta, Georgia, United States
• St. Luke's Idaho Cardiology Associates — Boise, Idaho, United States
• Fox Valley Cardiovascular Consultants — Aurora, Illinois, United States
• Midwest Heart Foundation — Lombard, Illinois, United States
• Northern Indiana Research Alliance — Fort Wayne, Indiana, United States
• The Care Group — Indianapolis, Indiana, United States
• Cardiovascular Associates — Louisville, Kentucky, United States
• Maine Medical Center — Portland, Maine, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• University of Michigan Medical Center — Ann Arbor, Michigan, United States
• William Beaumont Hospital — Royal Oak, Michigan, United States
• St. Mary's Duluth Clinic — Duluth, Minnesota, United States
• Minneapolis Heart Institute — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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