SNIFF 120: Study of Nasal Insulin to Fight Forgetfulness (120 Days)

Completed · Phase 2 · Has a placebo group

Conditions studied: Mild Cognitive Impairment, Alzheimer's Disease

In brief

The purpose of this study is to find out if insulin, when administered as a "nasal spray" into the nasal passages, improves memory in adults with mild cognitive impairment (MCI) or Alzheimer's disease.

Key facts

Study ID

NCT00438568

Run by

University of Washington

People needed

173

Starts

2006-06-01

Expected to finish

2011-12-01

Last updated by the study team

2012-09-14

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 55 or greater
• Good physical health
• Memory impairment with a diagnosis of mild cognitive impairment (MCI) or Alzheimer's disease (AD)
• Participants on stable doses of Memantine (Namenda) or cholinesterase inhibitors will be eligible

You may not qualify if…

• Chronic sinus problems/allergies with chronic use of nasal decongestants or antihistamines
• Significant neurologic disease that might affect cognition (other than AD), such as stroke, Parkinson's disease, multiple sclerosis, severe head injury with loss of consciousness for more than 30 minutes or with permanent neurologic symptoms
• Significant medical illness or organ failure, such as uncontrolled hypertension or cardiovascular disease, chronic obstructive pulmonary disease, liver disease, or kidney disease
• Preexisting diabetes or current or previous use of hypoglycemic agents or insulin; participants will be excluded if they have a fasting blood sugar greater than 165 on baseline OGTT
• Clinically significant elevations in liver function tests, cholesterol, or triglycerides
• Major psychiatric disorders (e.g., untreated major depression and schizophrenia)
• Chronic use of the following types of medications: anti-psychotic, anxiolytic, and opiates

Where it is running

• Veterans Administration Puget Sound Health Care System — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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