Efficacy/Safety of Verteporfin Photodynamic Therapy and Ranibizumab Compared With Ranibizumab in Patients With Subfoveal Choroidal Neovascularization

Completed · Phase 3 · Has a placebo group

Conditions studied: Macular Degeneration, Choroidal Neovascularization

In brief

This study evaluated the effect of combination therapy with verteporfin photodynamic therapy and ranibizumab on visual acuity and anatomic outcomes compared to ranibizumab monotherapy and the durability of response observed in patients with choroidal neovascularization secondary to age-related macular degeneration.

Key facts

Study ID

NCT00436553

Run by

Novartis

People needed

321

Starts

2007-02-01

Expected to finish

2009-10-01

Last updated by the study team

2011-04-19

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects of either gender age 50 years or older
• Subfoveal choroidal neovascularization (CNV) due to age-related macular degeneration (AMD)

You may not qualify if…

• Choroidal neovascularization due to causes other than AMD
• Prior treatment for neovascular AMD in the study eye
• Other protocol-defined inclusion/exclusion criteria may apply

Where it is running

• Novartis Investigative Site — Tucson, Arizona, United States
• Novartis Investigative Site — Beverly Hills, California, United States
• Novartis Investigative Site — Oakland, California, United States
• Novartis Investigative Site — Pasadena, California, United States
• Novartis Investigative Site — Sacramento, California, United States
• West Coast Retina Medical Group Inc. - 185 Berry St. Suite 130 — San Francisco, California, United States
• Novartis Investigative Site — Santa Ana, California, United States
• Novartis Investigative Site — Denver, Colorado, United States
• Novartis Investigative Site — ‘Aiea, Hawaii, United States
• Novartis Investigative Site — Iowa City, Iowa, United States
• Novartis Investigative Site — Wichita, Kansas, United States
• Novartis Investigative Site — Lexington, Kentucky, United States
• Novartis Investigative Site — Paducah, Kentucky, United States
• Novartis Investigative Site — Baltimore, Maryland, United States
• Novartis Investigative Site — Grand Rapids, Michigan, United States
• Novartis Investigative SIte — Royal Oak, Michigan, United States
• Novartis Investigative Site — Williamsburg, Michigan, United States
• Novartis Investigative Site — Independence, Missouri, United States
• Novartis Investigative Site — St Louis, Missouri, United States
• Novartis Investigative Site — Toms River, New Jersey, United States
• Novartis Investigative Site — Lynbrook, New York, United States
• Novartis Investigative Site — Rochester, New York, United States
• Novartis Investigative Site — Beachwood, Ohio, United States
• Novartis Investigative Site — Cincinnati, Ohio, United States
• Novartis Investigative Site — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.