Procurement of Tissue Samples for Cell Cultures and Analyses
Stopped early
Conditions studied: Bone Regeneration, Fracture Healing, Cell Culture Techniques, Tissue Engineering, Differentiation
In brief
This study will determine if bone marrow stromal cells can be used as a graft for regeneration of bony defects. These cells have the ability to form new bone and to support the formation of blood. Stromal cells have been identified in other tissues, such as the dermis (underside of skin), spleen, thymus and fat, but it is not known whether these cells can make bone and support blood formation as well as bone marrow stromal cells. Patients undergoing surgery at Suburban Hospital in Bethesda, Maryland, in which some of the bone, dermis, spleen, thymus or fat tissue is removed may be eligible for this study. For this study, a small piece of the tissue that is removed during surgery for examination by a pathologist will be used for research. Stromal cells from the specimen will be collected and grown in the laboratory. The genes and proteins in the different cell types will be compared, and the ability of stromal cells from the different tissues to make bone and to support the formation of blood will be studied.
Key facts
- Study ID
- NCT00435877
- Run by
- National Institute of Dental and Craniofacial Research (NIDCR)
- People needed
- 2
- Starts
- 2007-01-29
- Expected to finish
- 2012-11-05
- Last updated by the study team
- 2019-12-17
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Any patient that has a history of metabolic bone disease.
- Any patient that has cancer of any type, or has been treated for cancer of any type.
- Any patient that has been treated with a reagent known to affect bone metabolism (bisphosphonates, steroids, vitamin D)
Where it is running
- Suburban Hospital — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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