Human Papillomavirus (HPV) and Risk of Cervical Precancer and Cancer

Completed

Conditions studied: Cervical Neoplasia

In brief

Background: * In most women, HPV infection does not cause symptoms and the infection goes away on its own. In a small percentage of women, the HPV infection does not go away and sometimes can result in cervical precancer or cancer. * There are several different types of HPV. A better understanding of which types are related to cervical precancer and cancer may help guide doctors in clinical management of women who test positive for HPV and better understand why some women develop disease while others do not. Objectives: * To determine whether certain types of HPV are more risky than others and if so, whether they warrant separate detection in screening for cervical precancer and cancer. * To determine if lasting infection by different HPV types carry different risk of cervical precancer and cancer. * To determine what viral and genetic factors influence the development of cervical precancer and cancer. * To evaluate new HPV tests and new biomarkers of cervical cancer risk. Eligibility: -Women 30 years of age and older who are in the cervical cancer screening program at the Kaiser Permanente health plan in Northern California. Women who tested positive for HPV and a random sample of women who tested negative for the virus are included. Design: -Data about participants genetic background and the type of carcinogenic HPV with which they are infected are analyzed.

Key facts

Study ID
NCT00435214
Run by
National Cancer Institute (NCI)
People needed
131110
Starts
2007-01-29
Expected to finish
2020-04-30
Last updated by the study team
2020-05-01

Who can join

Age: 21 and older, up to 100. Sex: female. Healthy volunteers: not accepted.

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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