Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans

Completed · Not applicable · Has a placebo group

Conditions studied: Healthy

In brief

Objectives: This proposal addresses the overall hypothesis that ambient fine particulate matter exerts cardiovascular health effects via alteration of endothelial homeostasis, through a mechanism mediated by oxidative stress. This project will use a controlled human inhalation exposure to diesel exhaust particulate (DEP) as a model to address the following objectives: 1) Determine whether exposure to inhaled DEP is associated with endothelial dysfunction in a concentration-related manner; 2) Determine whether exposure to inhaled DEP is associated with evidence of systemic oxidative stress; and 3) Determine whether antioxidant supplementation blunts the DEP effect on endothelial function.

Key facts

Study ID

NCT00434005

Run by

University of Washington

People needed

24

Starts

2008-07-01

Expected to finish

2010-08-01

Last updated by the study team

2013-01-16

Who can join

Age: 18 and older, up to 49. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy adults aged 18-49.

You may not qualify if…

• Nonsmokers, no history of hypertension, asthma, diabetes, hypercholesterolemia, or other chronic conditions requiring ongoing medical care. No recent history of antioxidant, vitamin/mineral/botanical, or fatty acid supplementation beyond a daily multi-vitamin.

Where it is running

• Northlake Laboratory — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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