BOAT: Beta Blocker Uptitration With OptiVol After Cardiac Resynchronization Therapy (CRT)

Stopped early · Phase 4

Conditions studied: Congestive Heart Failure

In brief

Many heart failure patients are unable to reach target beta blocker doses. This study will address whether cardiac resynchronization therapy (CRT) will enable uptitration of beta-blockers to target doses and whether it will favorably affect remodeling by reducing left ventricular end systolic volume (LVESV), with measurable clinical benefit, beyond CRT alone (without changes in beta-blocker dose).

Key facts

Study ID

NCT00433043

Run by

St. Luke's-Roosevelt Hospital Center

People needed

2

Starts

2007-01-01

Expected to finish

2009-05-01

Last updated by the study team

2015-10-30

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• NYHA III-IV
• QRS > 120 msec
• On medical therapy, but beta blocker dose not @ target (carvedilol 25 bid, metoprolol succinate 200 qd)

You may not qualify if…

• QRS < 120 msec
• On target beta blocker dose

Where it is running

• St. Lukes Roosevelt Hospital — New York, New York, United States
• University of Rochester — Rochester, New York, United States
• Jefferson Medical College — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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