Study of the Effect of Intramuscular Ephedrine on the Incidence of Nausea and Vomiting During Elective Cesarean Section

Completed · Phase 2 · Has a placebo group

Conditions studied: Nausea, Vomiting, Cesarean Section

In brief

The purpose of this research study is to investigate if the incidence of nausea and vomiting that subjects experience during and after a Cesarean section can be reduced by giving a shot of the drug ephedrine into the thigh muscle at the time of spinal anesthesia administration.

Key facts

Study ID

NCT00432991

Run by

Weill Medical College of Cornell University

People needed

53

Starts

2007-02-01

Expected to finish

2010-09-01

Last updated by the study team

2017-05-22

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Must be pregnant with a single baby
• Must be at term in their pregnancy (estimated gestational age of at least 38 weeks)
• Must be scheduled for an elective Cesarean section
• Must be between 60-70" tall
• Must be free of severe systemic disease (ASA class I or II)

You may not qualify if…

• Contraindication to spinal anesthesia
• Any allergy to any of the medications included in the study
• History of pregnancy-induced hypertension or preeclampsia
• History of preexisting hypertension
• Diabetes mellitus
• Hyperemesis gravidum
• Previous perioperative nausea and vomiting
• History of motion sickness
• Women carrying a fetus with a known abnormality will also be excluded from the study

Where it is running

• New York-Presbyterian Hospital; Weill Medical College of Cornell — New York, New York, United States

Full record on ClinicalTrials.gov

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