Redesigning Cardiac Surgery to Reduce Neurologic Injury
Completed
Conditions studied: Cardiovascular Disease, Surgery
In brief
Neurologic injuries are frequent and devastating complications following cardiac surgery. Previous work conducted by our research group and others has identified the principal mechanisms creating both overt and subtle neurologic injuries after cardiac surgery. Current work by our group has identified that the causes (thrombotic/lipid emboli, cerebral hypoperfusion \& hypotension, and gaseous emboli) of these injuries are byproducts of processes of surgical and perfusion care. This insight suggests that the redesign of clinical strategies and techniques to prevent the occurrence of these intraoperative sources of damage may provide an opportunity to reduce the risk of neurologic injury after cardiac surgery. The goal of this research is to identify modifiable clinical strategies and techniques of surgical and perfusion care associated with the causes (thrombotic/lipid emboli, cerebral hypoperfusion \& hypotension, and gaseous emboli) of neurologic injury secondary to coronary artery bypass graft (CABG) surgery, and subsequently to redesign these processes to reduce a patient's risk of a neurologic injury.
Key facts
- Study ID
- NCT00432536
- Run by
- Dartmouth-Hitchcock Medical Center
- People needed
- 469
- Starts
- 2002-10-01
- Expected to finish
- 2012-02-01
- Last updated by the study team
- 2013-05-16
Who can join
Age: 40 and older, up to 89. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients aged 40-89 years undergoing nonemergency coronary revascularization or valve procedures with or without the use of a cardiopulmonary bypass circuit.
You may not qualify if…
- Undergoing concomitant procedures besides cardiac surgery
Where it is running
- Maine Medical Center — Portland, Maine, United States
- Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States
- Catholic Medical Center — Manchester, New Hampshire, United States
Full record on ClinicalTrials.gov
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