Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus

Running, not enrolling

Conditions studied: Barrett Esophagus, Esophageal Neoplasm, Gastroesophageal Reflux

In brief

The purpose of this study is to determine if there are any early changes in DNA markers of blood and esophageal tissue in people with gastric reflux, Barrett's esophagus or esophageal cancer that can warn of a progression to esophageal cancer.

Key facts

Study ID

NCT00431756

Run by

Johns Hopkins University

People needed

600

Starts

2002-05-01

Expected to finish

2026-08-31

Last updated by the study team

2026-06-17

Who can join

Age: 18 and older, up to 95. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• People who are undergoing upper endoscopy as part of their medical care with a history of esophageal cancer, Barrett's esophagus, or upper gastrointestinal symptoms.

You may not qualify if…

• People who are are currently having chemotherapy, or who have completed chemotherapy within the last 4 weeks.
• People who have ever had radiation treatments to their chest.

Where it is running

• Johns Hopkins Hospital — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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