Brain Activation Patterns in Schizophrenia After Computerized Cognitive Skills Training

Completed · Not applicable

Conditions studied: Schizophrenia

In brief

This project is a novel exploratory research project to investigate changes in activation patterns of the dorsolateral prefrontal cortex (DLPFC) in inpatients with schizophrenia who received a 12-week computerized cognitive remediation (CRT) program. The hypothesis is that patients receiving CRT will show greater increase in activation patterns in the brain as compared to controls, and the degree of brain activation will correlate with improvements in working memory.

Key facts

Study ID

NCT00431223

Run by

Manhattan Psychiatric Center

People needed

11

Starts

2006-09-01

Expected to finish

2008-09-01

Last updated by the study team

2020-10-06

Who can join

Age: 18 and older, up to 55. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Inpatient status
• Age 18 - 55
• Male gender (females are enrolled but will not be scanned)
• DSM-IV diagnosis of schizophrenia (all subtypes) and schizoaffective disorder
• illness duration > 5 years
• MMSE score > 24 (inclusive) at screening
• Stable dose of oral atypical antipsychotic for at least 4 weeks prior to study entry
• Total PANSS score > 60 at screening
• Capacity and willingness to give written informed consent
• Patients deemed not ready to be discharged within the next 12 weeks

You may not qualify if…

• Inability to read or speak English
• Documented disease of the central nervous system
• History of intellectual impairment pre-dating onset of symptoms of psychosis (e.g. mental retardation)
• Clinically significant or unstable cardiovascular, renal, hepatic, gastrointestinal, pulmonary, or hematological conditions; HIV positive
• Any medical condition rendering the subject unable to receive an fMRI scan

Where it is running

• Manhattan Psychiatric Center — New York, New York, United States

Full record on ClinicalTrials.gov

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