Effects of Pentazocine Versus Lorazepam on Manic Symptoms

Completed · Phase 2

Conditions studied: Bipolar Disorder, Schizoaffective Disorder, Manic Disorder, Mania, Manic State

In brief

Pilot data indicates that pentazocine decreases manic symptoms in hospitalized individuals. To follow up these initial findings, we plan to conduct a larger, more rigorous, double-blind study. We will examine whether pentazocine, an agent with kappa-opiate activity, decreases manic symptoms.

Key facts

Study ID

NCT00431184

Run by

Mclean Hospital

People needed

19

Starts

2007-01-01

Expected to finish

2011-03-01

Last updated by the study team

2019-03-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• bipolar or schizoaffective disorder
• currently manic
• no acute medical issues
• no substance withdrawal

You may not qualify if…

• unable to give informed consent
• using opiates for pain management
• history of head injury, dementia, or mental retardation
• seizure disorder
• glaucoma
• unstable cardiac condition or arrhythmia
• moderate-severe pulmonary disease
• pregnancy

Where it is running

• McLean Hospital — Belmont, Massachusetts, United States

Full record on ClinicalTrials.gov

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