Surgery With or Without Docetaxel and Leuprolide or Goserelin in Treating Patients With High-Risk Localized Prostate Cancer
Running, not enrolling · Phase 3
Conditions studied: Prostate Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as goserelin and leuprolide, may stop the adrenal glands from making androgens. Giving docetaxel and leuprolide or goserelin before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. It is not yet known whether giving docetaxel and leuprolide or goserelin before surgery is more effective than surgery alone in treating patients with prostate cancer. PURPOSE: This randomized phase III trial is studying docetaxel and leuprolide or goserelin to see how well they work when given before surgery compared with surgery alone in treating patients with high-risk localized prostate cancer.
Key facts
- Study ID
- NCT00430183
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 788
- Starts
- 2007-05-08
- Expected to finish
- 2030-10-01
- Last updated by the study team
- 2023-02-09
Who can join
Age: 18 and older. Sex: male. Healthy volunteers: not accepted.
Where it is running
- Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital — Fairbanks, Alaska, United States
- Alta Bates Summit Comprehensive Cancer Center — Berkeley, California, United States
- Peninsula Medical Center — Burlingame, California, United States
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
- Sutter Health - Western Division Cancer Research Group — Novato, California, United States
- University of California Davis Cancer Center — Sacramento, California, United States
- Naval Medical Center - San Diego — San Diego, California, United States
- California Pacific Medical Center - Pacific Campus — San Francisco, California, United States
- Sutter Pacific Medical Foundation — Santa Rosa, California, United States
- Tahoe Forest Cancer Center — Truckee, California, United States
- Sutter Solano Medical Center — Vallejo, California, United States
- University of Colorado Cancer Center at UC Health Sciences Center — Aurora, Colorado, United States
- Denver Health Medical Center — Denver, Colorado, United States
- Veterans Affairs Medical Center - Denver — Denver, Colorado, United States
- Shaw Regional Cancer Center — Edwards, Colorado, United States
- Valley View Hospital Cancer Center — Glenwood Springs, Colorado, United States
- Montrose Memorial Hospital Cancer Center — Montrose, Colorado, United States
- Helen and Harry Gray Cancer Center at Hartford Hospital — Hartford, Connecticut, United States
- Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center — Hartford, Connecticut, United States
- Yale Cancer Center — New Haven, Connecticut, United States
- Eastern Connecticut Hematology and Oncology Associates — Norwich, Connecticut, United States
- Veterans Affairs Medical Center - West Haven — West Haven, Connecticut, United States
- Tunnell Cancer Center at Beebe Medical Center — Lewes, Delaware, United States
- CCOP - Christiana Care Health Services — Newark, Delaware, United States
- Providence Cancer Center — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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