Sustained Release d-Amphetamine & Buprenorphine on Drug Seeking Behavior in Opioid & Cocaine Dependent Individuals

Completed

Conditions studied: Heroin Dependence, Opioid-Related Disorders, Cocaine Abuse or Dependence

In brief

The purpose of this study is to determine whether maintenance on different oral doses of sustained release d-amphetamine (SR-AMP) combined with constant-dose sublingual buprenorphine (BUP) is safe and well tolerated and decreases self-administration of cocaine alone or combined with hydromorphone (HYD). Secondary aims are to determine whether SR-AMP attenuates the subjective and physiological effects of cocaine during drug sampling periods prior to choice opportunities.

Key facts

Study ID

NCT00429767

Run by

Wayne State University

People needed

16

Starts

2007-01-01

Expected to finish

2010-01-01

Last updated by the study team

2012-06-05

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Opioid dependent and Cocaine abuse or dependence, as determined by structured clinical interview for DSM-IV (SCID) and Addiction Severity Index (ASI)
• Positive urine test for opiates and cocaine
• Willing to use an adequate form of contraception for the duration of the study
• Reads and writes English

You may not qualify if…

• Psychiatric illness, as determined by the DSM-IV criteria
• History of, or current neurological disease, including structural abnormalities, seizures, infectious disease, history of other neurological diseases or head trauma.
• History of cardiovascular disease, myocardial infarction, chest pain or palpations on exertion or drug use
• Systolic blood pressure greater than 160 or less than 95 mmHg; Diastolic blood pressure >95 mmHg
• Clinically abnormal ECG
• Pulmonary disease, including asthma, obstructive pulmonary disease, cor pulmonale, tuberculosis
• Systemic disease (e.g., endocrinopathies, liver or kidney failure, myxedema, hypothyroidism, Addison's disease, autoimmune disease)
• Current alcohol or sedative drug dependence
• Pregnant or breastfeeding
• Currently receiving treatment for a Substance Abuse/Dependence Disorder or seeking treatment
• Been in a research study within the last 30 days
• Known phobia of injections

Where it is running

• Wayne State University — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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