Using the Energy Gap to Prevent Weight Regain

Completed · Not applicable

Conditions studied: Obesity

In brief

The major challenge in obesity treatment is not producing weight loss but in preventing that weight from being regained. There are many different methods to lose weight, but there are no recommendations for how you can best achieve long-term weight loss maintenance. Despite the method used to reduce one's body weight, very few of these individuals are able to keep their weight off permanently. This project aims to identify how much activity is necessary to prevent weight regain after weight loss.

Key facts

Study ID

NCT00429650

Run by

University of Colorado, Denver

People needed

175

Starts

2007-07-01

Expected to finish

2014-01-01

Last updated by the study team

2019-06-28

Who can join

Age: 19 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All ethnic groups and both genders
• Age: Lower age limit: 19 years; Upper age limit: 45 years
• Body-mass Index: Lower BMI limit: 30 kg/m2; Upper BMI limit: 40 kg/m2 and weight stable within +/- 5 pounds in the last 6 months, and currently at maximum non pregnant body weight (+/- 5%)
• A negative treadmill stress test or subsequent follow up cardiac testing for cardiac ischemia.

You may not qualify if…

• History of cardiovascular disease, including coronary artery disease, congestive heart failure, \& unstable angina, or uncontrolled hypertension ( > 140/90 mm Hg)
• Currently smoking or stopped smoking in the last 12 months
• Medications affecting weight, energy intake, or energy expenditure in the last 6 months
• Use of oral steroids within the last 12 months
• History of stroke or seizures, thyroid disease, type 1 or 2 diabetes, Cushings syndrome, cerebrovascular, renal disease, hepatic disease, arrhythmias
• Cancer requiring treatment in the past 5 years, with the exception of skin cancers other than melanoma
• Infectious diseases: Self-reported HIV positivity or Active tuberculosis
• Weight loss or weight gain of > 5% in past 6 months for any reason except post-partum weight loss
• Likely to move away in next 1.5 years
• Inability to adhere to the program such as inability to increase walking
• Currently pregnant, lactating or less than 6 months post-partum
• Major psychiatric disorder: Exclusions related to medications -Antipsychotic agents (these include, but are not limited to: Haldol, Loxitane, Mellaril, Navane, Prolixin, Stelazine, Thorazine, and Trilafon)
• Current depression by history or Beck Depression Inventory (BDI)
• Currently being treated for psychological condition

Where it is running

• Center for Human Nutrition — Denver, Colorado, United States

Full record on ClinicalTrials.gov

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