Immunotherapy for Peanut Allergy
Completed · Not applicable
Conditions studied: Allergy
In brief
Currently, when a food allergy is diagnosed, the "standard of care" is strict avoidance of the allergic food and ready access to self-injectable epinephrine. Yet, accidental ingestions do occur. Unfortunately, for a ubiquitous food such as peanut, the possibility of an inadvertent ingestion is great. It is estimated that over 50% of individuals who are allergic to peanuts will have an accidental reaction to peanuts over a 2-year period. The purpose of this study is to determine if peanut sublingual immunotherapy (SLIT) reduces the number and/or symptoms of accidental peanut ingestion in peanut allergic subjects. We would anticipate that the subjects on the peanut SLIT protocol would experience few adverse effects with accidental peanut ingestion over the course of the two years of SLIT. The primary endpoint to evaluate the effectiveness of SLIT will be a negative DBPCFC to peanuts (8 grams) at the completion of the two years of the study.
Key facts
- Study ID
- NCT00429429
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 7
- Starts
- 2006-04-01
- Expected to finish
- 2011-05-01
- Last updated by the study team
- 2016-06-20
Who can join
Age: 6 and older, up to 35. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects between 6 and 35 years of age
- Diagnosed with peanut allergy by positive prick skin test, CAP FEIA of 15 Ku/L or greater
- History of significant clinical symptoms within one hour after ingestion of peanuts
- Family's compliance with all study visits
You may not qualify if…
- Subjects with medical history preventing a BDPCFC to peanut
- Subjects unable to cooperate with challenge procedure
- Subjects unable to be reached by telephone for follow-up
- Subjects with a history of severe anaphylaxis to peanut
Where it is running
- University of North Carolina — Chapel Hill, North Carolina, United States
Full record on ClinicalTrials.gov
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