3T Endorectal Magnetic Resonance Spectroscopic Imaging (MRSI) of Prostate

Stopped early · Not applicable

Conditions studied: Prostate Cancer

In brief

The objective of this study is to evaluate the feasibility of 3T magnetic resonance spectroscopic imaging (MRSI) of the prostate in improving the spectral resolution, using a perfluorocarbon compound (PFC)-filled endorectal coil. Specific Aim 1: To compare the spectral quality, measured in Hz (linewidth), of 3T MRSI performed with an air-filled endorectal coil (AIR-MRSI) and a PFC-filled endorectal coil (PFC-MRSI). Specific Aim 2: To compare the quality of spectra of PFC-MRSI by grading the overall quality of MRSI data of each patient subjectively as being "excellent," "good," "fair," "poor," and "non-diagnostic," based on the status of subjective spectral resolution of Cho, Cr and Po peaks, signal to noise ratio (SNR), baseline distortion, and fat contamination.

Key facts

Study ID

NCT00429338

Run by

M.D. Anderson Cancer Center

People needed

8

Starts

2007-01-01

Expected to finish

2013-10-01

Last updated by the study team

2015-01-09

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Newly diagnosed biopsy proven prostate carcinoma who are referred to Diagnostic Imaging for magnetic resonance imaging (MRI) / magnetic resonance spectroscopic imaging (MRSI)
• No previous radiation to prostate or pelvis
• No hormonal treatment for prostate
• The interval between the biopsy and magnetic resonance spectroscopic imaging (MRSI): more than 6 weeks
• Informed consent

You may not qualify if…

• Contraindications for MRI (e.g. cardiac pacemaker)
• Allergy to Latex
• Contraindications for magnetic resonance spectroscopic imaging (MRSI) (e.g. history of abdomino-perineal resection of rectum)
• Metals or any conditions (e.g. hip prosthesis) that can distort the local magnetic field
• Previous prostate surgery for prostate carcinoma (including, transurethral resection of the prostate (TURP) and cryosurgery), local or systemic treatment for prostate carcinoma (e.g. radiation, androgen deprivation), pelvic radiation (e.g. rectal cancer), rectal surgery, BCG for bladder cancer
• Children (<18 years)

Where it is running

• UT MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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