An Open-label, Exploratory Trial to Assess Gastric Acid Control in Critically Ill Subjects Receiving Nexium

Completed · Phase 4

Conditions studied: Gastric Ulcer

In brief

This study is being done to see if Nexium I.V. can reduce and control stomach acid in mechanically ventilated, critically ill patients in an Intensive Care Unit setting.

Key facts

Study ID

NCT00428701

Run by

AstraZeneca

People needed

40

Starts

2006-10-01

Expected to finish

2006-11-01

Last updated by the study team

2011-01-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Critically ill male or female subjects 18 years or older who have a baseline gastric aspirate pH less then or equal to 4
• Subjects admitted to an ICU requiring mechanically ventilated
• Subjects will have at least one additional stress ulcer risk factor

You may not qualify if…

• Anticipated use of pre-pyloric enteral feeding after screening until the end of study
• Physician estimated survival of less then 96 hours
• Anticipation of major surgery within 96 hours of study enrollment

Where it is running

• Research SIte — Newark, Delaware, United States
• Research Site — Shreveport, Louisiana, United States
• Research Site — Hershey, Pennsylvania, United States
• Research Site — Memphis, Tennessee, United States
• Research Site — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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