Local Anesthetic Treatments for Overactive Bladder

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Overactive Bladder

In brief

The purpose of this study is to determine whether alkalized lidocaine instilled into the bladder is effective in the treatment of overactive bladder (OAB).

Key facts

Study ID

NCT00427648

Run by

Frank Tu

People needed

22

Starts

2006-03-01

Expected to finish

2010-05-01

Last updated by the study team

2020-03-06

Who can join

Age: 18 and older, up to 100. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female patient, 18 years of age and older
• Overactive bladder defined as:
• Urinary frequency defined as eight or more voids in a 24 hour period > 50% of days of the week
• Symptoms of urgency
• Symptoms of at least three months duration

You may not qualify if…

• Positive urine culture in the past month, or more than 3 episodes of bladder infection in the last 2 months
• Stress or overflow urinary incontinence (determined by clinician) if more than 14 episodes of urinary incontinence per week; also insensate incontinence
• Pregnancy
• Seizure disorder or clinically significant renal disease, allergy to lidocaine, uninvestigated hematuria, or history of urinary/reproductive tract malignancy
• Post-void residual more than 200 cc

Where it is running

• NorthShore University HealthSystem — Evanston, Illinois, United States
• NorthShore University HealthSystem — Park City, Illinois, United States

Full record on ClinicalTrials.gov

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