Effectiveness of Blood Clot Medication With Concomitant Blood Pressure Medication

Status unconfirmed

Conditions studied: ICU Patients 18 Years or Older.

In brief

Patients in intensive care units have higher risks for developing blood clots. Arixtra inhibits blood clot formation by binding with the blood clotting factor, Xa. Critical illnesses and, specifically, medications given in the ICU to increase arterial blood pressure (vasopressors) may impair the absorption of drugs like Arixtra that are given subcutaneously. The study will measure the levels of Arixtra in blood comparing those subjects who are and those subjects who are not on blood pressure medication.

Key facts

Study ID

NCT00424281

Run by

Wayne State University

People needed

40

Starts

2007-02-01

Expected to finish

2010-01-01

Last updated by the study team

2007-01-19

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ICU patients 18 or over, weight 50 kg or more in the ICU will be enrollment eligible. Pregnant women and those with neuraxial anesthesia, renal or liver problems, or BMI over 40 are not eligible.

You may not qualify if…

• Patients under 18, weight less than 50 kg, pregnant women and those with neuraxial anesthesia, renal or liver problems, or BMI over 40 are not eligible.

Where it is running

• Harper University Hospital, ICU — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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