Collection of Heart Tissue Sample During Open Heart Surgery
Completed
Conditions studied: Ischemia
In brief
This study will collect heart tissue that is routinely removed and discarded during open-heart surgery. The Cardiology Branch of the NHLBI is conducting a variety of laboratory experiments that require a sample of heart tissue. A segment of tissue is routinely cut out of the right atrial appendage of the heart during open-heart surgery to allow the heart-lung bypass machine to be attached to the heart for protection during surgery. This small tissue sample is not re-attached after the bypass machine is removed, but usually destroyed as medical waste.' People between 18 and 80 years of age who are scheduled to undergo coronary artery bypass surgery or aortic valve replacement surgery may be eligible for this study. Participants donate the right atrial appendage of the heart, which would normally be destroyed after their open-heart surgery. The tissue will be used by NHLBI investigators in studies directed at learning how to make the heart less sensitive to damage from a heart attack. The samples may be used, for example, to evaluate the effectiveness of known therapies, refine treatment approaches, identify potential new therapies, or explore opportunities for disease prevention.
Key facts
- Study ID
- NCT00423553
- Run by
- National Heart, Lung, and Blood Institute (NHLBI)
- People needed
- 0
- Starts
- 2007-01-11
- Expected to finish
- 2007-12-10
- Last updated by the study team
- 2017-07-02
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Subjects currently on oral sulfonylurea therapy for diabetes mellitus
- Subjects in atrial fibrillation or having had a history of atrial fibrillation in the 2-week period prior to surgery
- Subjects in clinical right heart failure as evidenced by greater than trace pedal edema, an elevated JVP and or by evidence of hepatic congestion.
- Subjects unable to give informed consent
Where it is running
- Suburban Hospital — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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