Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3c

Completed

Conditions studied: Healthy

In brief

This study will determine if gas can pass between the environment and the middle ear by way of the eardrum. This route of gas exchange was observed in animals but has not been studied in humans. If gas exchange across the eardrum is documented and the rate is sufficiently high, this can help explain certain past observations such as why middle ear pressure does not change very much in some children and adults when they have a cold or flu. The investigators also expect that the rate of gas exchange across the eardrum will depend on whether or not the eardrum has scarred or abnormally thin regions.

Key facts

Study ID

NCT00422851

Run by

University of Pittsburgh

People needed

45

Starts

2007-06-01

Expected to finish

2009-02-01

Last updated by the study team

2017-11-13

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-50 years old
• at least one intact and effusion-free middle ear

You may not qualify if…

• bilateral otitis media
• unable to remain relaxed and quiet for up to 2 hours

Where it is running

• ENT Research Center Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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