Effects of Micronized Fenofibrate on Fasting and Postprandial Lipoproteins, Inflammatory Mediators and Thrombosis
Completed · Not applicable
Conditions studied: Hypertriglyceridemia With the Metabolic Syndrome
In brief
This is a randomized placebo controlled clinical trial designed to investigate the effects of micronized fenofibrate on fasting and postprandial lipoproteins, oxidized fatty acids and lipoproteins, inflammatory mediators and thrombotic factors among hypertriglyceridemic individuals with two or more other characteristics of the metabolic syndrome.
Key facts
- Study ID
- NCT00422396
- Run by
- University of Michigan
- People needed
- 60
- Starts
- 2001-01-01
- Expected to finish
- 2002-04-01
- Last updated by the study team
- 2017-02-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- males and postmenopausal females 18 years of age with fasting triglycerides greater than or equal to 1.7 mmol/L and <6.9 mmol/L
- two or more of the following Adult Treatment Panel III (1) criteria of the metabolic syndrome: abdominal obesity (waist circumference >89 cm in females and >102 cm in males); low high-density lipoprotein cholesterol (HDL-C) (<1.3 mmol/L in women and <1.0 mmol/L in men); hypertension (systolic blood pressure >130 or diastolic blood pressure >85 mm Hg) or current drug therapy for hypertension; and impaired fasting glucose (between 6.1 mmol/L and 7.0 mmol/L).
You may not qualify if…
- included types 1 or 2 diabetes
- Body mass index >40 kg/m2
- Use of lipid-lowering therapies
- Oral hypoglycemic therapies
- Insulin
- Aspirin >81 mg daily
- Regular use of non-steroidal anti-inflammatory agents or cyclooxygenase-2 inhibitors, corticosteroids (oral and inhaled), anti-oxidants (including multivitamins), herbal or fiber supplements recent changes in type or formulation of hormone replacement therapy (in the last 6 months)
- Alcohol intake >3 drinks per day
- Untreated hypothyroidism or recent change (within 2 months) of thyroid replacement therapy
- Cigarette smoking (current or within the last 6 months)
Where it is running
- Northwestern University preventive Cardiology Center — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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