Genetics of Middle Ear Disease

Completed

Conditions studied: Otitis Media

In brief

The goal of this study is to identify the genes that contribute to susceptibility to recurrent/persistent middle ear disease. Five hundred families with at least 2 children who have undergone tympanostomy tube insertion will be enrolled. A blood sample will be obtained from the children who had tubes and any available parent (at least 1), as well as any siblings without significant histories of middle ear disease.

Key facts

Study ID

NCT00422136

Run by

University of Pittsburgh

People needed

2121

Starts

2002-07-01

Expected to finish

2009-07-01

Last updated by the study team

2017-11-14

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• families: 2 or more full sibs who had tympanostomy tubes inserted

You may not qualify if…

• major congenital malformations
• medical conditions with a predisposition for OM (e.g. cleft palate, Down syndrome, or other craniofacial malformations
• cared for in the Intensive Care Unit as neonate
• been on assisted ventilation
• known sensorineural hearing loss

Where it is running

• ENT Research Center, Children's Hospital of Pittsburgh of UPMC — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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