Low Dose Vasopressin in Traumatic Shock

Stopped early · Early Phase 1

Conditions studied: Injuries, Shock, Traumatic

In brief

Hypothesis: We hypothesize that resuscitation regimens which minimize the total volume of resuscitation fluid, while restoring organ perfusion, will lead to lower morbidity and mortality in critically ill patients following trauma.

Key facts

Study ID

NCT00420407

Run by

The University of Texas Health Science Center at San Antonio

People needed

81

Starts

2007-02-01

Expected to finish

2011-02-01

Last updated by the study team

2019-06-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• To be eligible for enrollment in the study, a patient must meet all of the follow criteria at assessment:
• Patient is a male or female patient presumed to be at least 18 years of age;
• Patient has a systolic blood pressure < 90 mmHg;
• Patient has clinical evidence of acute traumatic injury;
• Infusion of study drug must start within one hour following SBP (systolic blood pressure) < 90 mmHg

You may not qualify if…

• A patient meeting any one of the following criteria at hospital assessment is not eligible for enrollment:
• Patient is admitted to one of the study hospitals' Emergency Department greater than six hours after injury;
• Patient has received greater than 4 liters fluid since time of injury;
• Patient is enrolled in another shock trial;
• Patient is asystolic or requires CPR (cardiopulmonary resucitation) prior to randomization;
• Female patient is pregnant by report or suspicion;
• Patient has known "Do Not Resuscitate" orders or visible/identifiable method of objection to participation (e.g., exclusion bracelet);

Where it is running

• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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