Prevention of Atrial Fibrillation Following Esophagectomy

Completed · Phase 4

Conditions studied: Atrial Fibrillation, Esophagectomy

In brief

The investigators hypothesize that the medication amiodarone decreases the incidence of atrial fibrillation (AF) following esophagectomy surgery. Their specific aims are to: Determine the effectiveness of amiodarone for the prevention of AF following esophagectomy surgery; Determine the influence of the prevention of AF following esophagectomy surgery on post-surgical duration of stay in the Intensive Care Unit ICU)and duration of post-surgical hospital stay; and Determine the safety of amiodarone for the prevention of AF following esophagectomy surgery.

Key facts

Study ID

NCT00420017

Run by

Indiana University

People needed

80

Starts

2005-09-01

Expected to finish

2008-11-01

Last updated by the study team

2013-09-18

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females over the age of 40
• Scheduled to undergo esophagectomy

You may not qualify if…

• History of atrial fibrillation
• Prior severe side effects from amiodarone
• Elevated liver enzymes >3 times the upper limit of normal (UNL)
• Corrected QT interval > 450 ms
• Receiving class Ia or class III antiarrhythmics

Where it is running

• Indiana University Hospital — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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