Antenatal Betamethasone Compared to Dexamethasone - "BETACODE TRIAL"

Completed · Not applicable

Conditions studied: Respiratory Distress Syndrome, Intraventricular Hemorrhage, Neonatal Mortality

In brief

Antenatal corticosteroids result in substantial decrease in neonatal morbidity and mortality by specifically reducing the risk of respiratory distress syndrome, intraventricular hemorrhage and neonatal death among premature infants. No human randomized study has formally compared betamethasone and dexamethasone, the preferred corticosteroids for antenatal therapy, with regards to their effectiveness in reducing neonatal morbidities and mortality. Our objective was to compare betamethasone with dexamethasone in terms of effectiveness in reducing perinatal morbidities and mortality among preterm infants.

Key facts

Study ID

NCT00418353

Run by

University of Oklahoma

Starts

2002-08-01

Expected to finish

2005-04-01

Last updated by the study team

2007-01-04

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women in preterm labor with intact membranes
• Women with preterm premature rupture of membranes
• Women been delivered for fetal and maternal indications
• Gestational age between 24 and 33 6/7 weeks'.

You may not qualify if…

• Clinical chorioamnionitis
• known major fetal structural anomalies,
• known fetal chromosomal abnormalities,
• prior antenatal steroid exposure,
• quadruplets and higher order multiple gestation
• Women who declined enrollment.

Where it is running

• Stony Brook University Hospital — Stony Brook, New York, United States

Full record on ClinicalTrials.gov

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