Cisplatin/Etoposide/Radiotherapy Followed by Consolidation Sorafenib for Inoperable Stage III Non-Small Cell Lung Cancer

Stopped early · Phase 1/Phase 2

Conditions studied: Non-Small Cell Lung Cancer

In brief

Sorafenib has demonstrated in vivo anti-tumor efficacy. This trial will evaluate the safety and preliminary efficacy of sorafenib following chemoradiation in locally advanced NSCLC.

Key facts

Study ID

NCT00417248

Run by

Nasser Hanna, M.D.

People needed

8

Starts

2007-06-01

Expected to finish

2008-04-01

Last updated by the study team

2016-07-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histological or cytological proof of non-small cell lung cancer (NSCLC).
• Measurable or non-measurable disease per RECIST.
• Unresectable Stage IIIA or IIIB disease as evaluated by imaging.
• Must be age ≥ 18 years at the time of consent.
• Written informed consent and HIPAA authorization for release of personal health information.
• Females of childbearing potential and males must be willing to use an effective method of contraception.
• Females of childbearing potential must have a negative pregnancy test within 7 days prior to being registered for initial therapy.

You may not qualify if…

• No prior chemotherapy or radiotherapy for lung cancer.
• No positive supraclavicular or scalene lymph nodes extending up into the cervical region.
• No superior sulcus (pancoast tumors).
• No malignant pleural effusions. The only exception is a patient with a pleural effusion visible only on CT scan (and not visible on CXR) OR deemed too small to tap.
• No clinically significant or malignant pericardial effusions.
• No CNS metastases.
• No unintended weight loss (> 5% body weight) in the preceding 90 days prior to registration for initial therapy.
• No treatment with any investigational agent within 30 days prior to being registered for initial therapy.
• No prior therapy with a Ras pathway inhibitor or anti-angiogenic agent.
• No other active cancers.
• Females must not be breastfeeding.
• No active clinically serious infections as judged by the treating investigator (> CTC v3, Grade 2) including known human immunodeficiency virus (HIV) infection or chronic Hepatitis B or C.
• No major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to registration for initial therapy.
• No anticipation of need for major surgical procedure during the course of the study.
• No minor surgical procedures such as fine needle aspirations or cone biopsies within 7 days prior to registration for initial therapy.
• No history of allergic reactions to drugs utilizing the vehicle polysorbate 80 + polyethylene glycol (etoposide).
• No history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to registration for initial therapy.
• No use inhibitors or inducers of the cytochrome p450 system CYP3A4 enzyme or other medications such as aprepitant, ketoconazole, itraconazole, quinidine, digoxin, cyclosporine, ritonavir, grapefruit products, St. John's Wort, rifampin (rifampicin), carbamazepine, phenytoin, dexamethasone, and phenobarbital.
• No evidence or history of bleeding diathesis or coagulopathy.
• No serious non-healing wound, ulcer, or bone fracture.
• No known or suspected allergy to sorafenib.
• No uncontrolled hypertension defined as systolic blood pressure > 150 mm Hg or diastolic pressure > 90 mm Hg, despite optimal medical management.
• No thrombolic or embolic events such as a cerebrovascular accident including transient ischemic attacks within 6 months prior to registration for initial therapy.
• No pulmonary hemorrhage/bleeding event ≥ CTCAE Grade 2 within 4 weeks prior to registration for initial therapy.
• No hemorrhage/bleeding event ≥ CTCAE Grade 3 within 4 weeks prior to registration for initial therapy.

Where it is running

• Medical & Surgical Specialists, LLC — Galesburg, Illinois, United States
• Fort Wayne Oncology & Hematology, Inc — Fort Wayne, Indiana, United States
• Center for Cancer Care at Goshen Health System — Goshen, Indiana, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• Horizon Oncology Center — Lafayette, Indiana, United States
• Medical Consultants, P.C. — Muncie, Indiana, United States
• Northern Indiana Cancer Research Consortium — South Bend, Indiana, United States
• Oncology Partners Network — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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