Programmed Intermittent Epidural Bolus Time Interval and Injection Volume
Completed · Not applicable
Conditions studied: Labor Pain
In brief
Studies suggest that administration of maintenance epidural solutions as programmed or automated intermittent boluses, rather than continuous infusions, result in lower bupivacaine consumption, decreased need for manual boluses by the anesthesiologist, and greater patient satisfaction. In this technique, the epidural maintenance dose is administered as a bolus by the infusion pump at regular intervals instead of as a continuous infusion. However, the optimal combination of bolus volume and dosing interval has not been determined. At one end of the spectrum, a small volume and short bolus dose interval will likely behave like a continuous infusion. At the other end of the spectrum, a large volume and long bolus dose interval may lead to an increased incidence of breakthrough pain. The purpose of this randomized, double-blind trial was to determine how manipulation of the programmed intermittent time interval and volume influences total drug use, quality of analgesia, and patient satisfaction during maintenance of labor analgesia. We hypothesized that manipulation of the programmed intermittent bolus time interval and volume during the maintenance of epidural labor analgesia influences total drug use, quality of analgesia and patient satisfaction.
Key facts
- Study ID
- NCT00417027
- Run by
- Northwestern University
- People needed
- 190
- Starts
- 2006-08-01
- Expected to finish
- 2009-04-01
- Last updated by the study team
- 2014-04-14
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Healthy
- nulliparous women
- term gestation (greater than or equal to 37 weeks gestation)
- spontaneous labor or with spontaneous rupture of membranes
You may not qualify if…
- Systemic disease (e.g., diabetes mellitus, hypertension, preeclampsia)
- use of chronic analgesic medications
- systemic opioid labor analgesia prior to the initiation of neuraxial labor analgesia
- cervical dilation less than 2cm or greater than 5cm at time of initiation of neuraxial analgesia
- delivery within 90 minutes of intrathecal injection
Where it is running
- Northwestern Memorial Hospital — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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