Correlations Between BNP & Dry Weight, and Between Troponin & Mortality, in Hemodialysis Patients

Status unconfirmed

Conditions studied: Kidney Failure, Chronic, Heart Failure, Congestive

In brief

Beta Natriuretic Peptide (BNP) is regarded as the most sensitive test for congestive heart failure (CHF). BNP has also been found to be highly predictive of other conditions including pulmonary hypertension, pulmonary embolism and in the general population where mild increases are associated with stroke and heart attack. BNP is also weakly and variably correlated with renal function. We believe that each dialysis patient will have an ideal or "dry" BNP level which will accurately and reproducibly reflect their optimal fluid status. Secondary hypotheses are that baseline BNP and troponin, as well as changes in BNP and troponin during dialysis, will be highly predictive of mortality and adequacy of dialysis.

Key facts

Study ID

NCT00416013

Run by

Eastern Virginia Medical School

People needed

151

Starts

2005-12-01

Expected to finish

2010-12-01

Last updated by the study team

2010-10-07

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All patients who complete dialysis, are 18 years or older or 85 years or less, and give informed consent will be eligible.

You may not qualify if…

• Inability to provide informed consent

Where it is running

• Eastern Virginia Medical School — Norfolk, Virginia, United States

Full record on ClinicalTrials.gov

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