Normobaric Oxygen Therapy in Acute Ischemic Stroke Trial

Stopped early · Phase 2

Conditions studied: Ischemic Stroke

In brief

The purpose of this study is to compare the safety and efficacy of treating individuals with acute ischemic stroke with normobaric oxygen therapy (NBO, given within 9 hours of symptom onset), to standard medical treatment.

Key facts

Study ID

NCT00414726

Run by

Massachusetts General Hospital

People needed

85

Starts

2007-01-01

Expected to finish

2009-06-01

Last updated by the study team

2017-10-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than or equal to 18 years.
• Acute ischemic stroke in whom treatment can potentially be started within 9 hours after symptom onset. If the symptom onset time is unknown, the time of onset will be defined as the midpoint between the time when the subject was last seen neurologically intact, and when found to have a neurological deficit.
• National Institutes of Health Stroke Scale (NIHSS) score 4 or greater.

You may not qualify if…

• Patients being actively considered for intravenous or intra-arterial thrombolysis will be excluded.
• Patients likely to have acute stroke intervention such as carotid endarterectomy or stent or angioplasty, hemicraniectomy, etc.
• Rapidly improving neurological deficits (transient ischemic attack).
• Known history of severe chronic obstructive pulmonary disease (Forced Expiratory Vital Capacity less than 1.0 or oxygen dependent).
• More than 3 L/min oxygen required to maintain peripheral arterial oxygen saturation above 92%.
• New York Heart Association Class III heart failure.
• Endotracheal intubation prior to enrollment or impending need for artificial ventilation.
• Coma (National Institutes of Health Stroke Scale item 1a score of 3).
• Suspected seizure at or after onset of stroke, or a known active seizure disorder.
• Blood glucose below 50 mg/dL or greater than 250 mg/dL prior to enrollment.
• Concurrent severe non-stroke medical illness requiring admission to a non-neurological intensive care unit
• Expected survival less than 90 days.
• Any condition that might limit neurological assessment or follow-up in the opinion of the investigator.
• Pre-menopausal women with a positive pregnancy blood test performed at admission.
• Inability to obtain consent from the patient or legally authorized representative.
• Active participation in another intervention study (e.g. investigational drug trial).
• Proven alternate etiology for stroke-like symptoms.

Where it is running

• Massachusetts General Hospital, ACC-729C — Boston, Massachusetts, United States
• Brigham and Women's Hospital, 75 Francis Street — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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