Using Ultrasonography to Predict Clinical Response to Intraarticular Corticosteroids in Knee Osteoarthritis
Completed · Not applicable
Conditions studied: Knee Osteoarthritis
In brief
The primary purposes of this study are the following: 1. To evaluate whether the presence of inflammatory knee osteoarthritis as determined by ultrasonography can be used as a clinical predictor of patient response to intra-articular corticosteroids. 2. To prospectively evaluate clinical responsiveness of intraarticular corticosteroids with the inflammatory phenotype of knee OA using a randomized, placebo controlled clinical design. 3. To evaluate whether lower extremity strength is improved with intraarticular corticosteroid injection. The investigators hypothesize that patients with signs of inflammation by ultrasonography such as synovitis and effusion will respond better to intraarticular corticosteroid injection.
Key facts
- Study ID
- NCT00414427
- Run by
- University of California, San Diego
- People needed
- 120
- Starts
- 2005-12-01
- Expected to finish
- 2009-06-01
- Last updated by the study team
- 2010-07-08
Who can join
Age: 40 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Both male and female patients are eligible for the study if they are between 40 and 80 years old, have symptomatic knee OA requiring treatment, and have not responded adequately to treatment with acetominophen or NSAIDs.
You may not qualify if…
- Severe OA as defined by radiographic Kellgren and Lawrence Grade IV
- The patient being wheel-chair bound
- Previous knee operation on the affected side within the past year or history of total knee arthroplasty (affected side)
- Any IA steroid or injections in the last 3 months or viscosupplementation in the last 6 months
- Local sepsis
- Local skin conditions
- Serious concomitant medical illness.
Where it is running
- Thorton Hospital — La Jolla, California, United States
- La Jolla Veterans Affairs Medical Center — San Diego, California, United States
Full record on ClinicalTrials.gov
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