National Active Surveillance Network and Pharmacogenomics of Adverse Drug Reactions in Children

Recruiting now

Conditions studied: Adverse Drug Reaction (ADR)

In brief

The purpose of the study is (1) to identify and collect samples from children and adults who take drugs and have adverse drug reactions AND children and adults who take drugs and do not experience any adverse drug effects; (2) to determine if genetic differences between the two groups contribute to causing the adverse drug reactions; and (3) to develop patient specific drug dosing guidelines to prevent future adverse drug reactions. We also wish to compare the use of prescription drugs, medical and hospital services and vital statistics between BC participants who experience adverse drug reactions and those who do not. Study hypothesis: Genetic differences may contribute to patients' response to drugs and may be responsible for adverse drug reactions.

Key facts

Study ID

NCT00414115

Run by

University of British Columbia

People needed

7000

Starts

2005-08-01

Expected to finish

2029-03-01

Last updated by the study team

2026-05-01

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Children under 19 years who have taken drugs.
• Biological parents of children who have had an ADR.
• Patients/parents who speak and understand English (except in Quebec).
• Adults (for validation of findings in children)

Where it is running

• Children's and Women's Health Centre of British Columbia — Vancouver, British Columbia, Canada (enrolling)

Full record on ClinicalTrials.gov

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