Vascular Remodeling and the Effects of Angiogenic Inhibition in Diabetic Retinopathy

Completed · Early Phase 1

Conditions studied: Diabetic Retinopathy

In brief

The retinal vasculature changes dramatically in patients with diabetic retinopathy especially between non-proliferative and proliferative disease. The retinal vasculature can be imaged and quantified using special dyes. This study will test whether the pattern of the retinal vasculature changes in patients with different levels of diabetic retinopathy can be quantified using computerized image analysis. In addition, the study will evaluate whether new drugs to treat diabetic retinopathy will be able to reverse these vascular changes.

Key facts

Study ID

NCT00411333

Run by

National Eye Institute (NEI)

People needed

100

Starts

2006-07-01

Expected to finish

2009-07-01

Last updated by the study team

2010-11-11

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Presence of mild, moderate, severe, or very severe non-proliferative diabetic retinopathy (defined as ETDRS level >10) in at least one eye (based on ETDRS criteria)

You may not qualify if…

• Any condition that might impair the patient's ability to give informed consent
• Any condition or media opacity that might impair the patient's ability to perform vision tests, color fundus photographs or fluorescein angiography
• Severe allergy or other contraindication to sodium fluorescein dye
• Participating in any other ophthalmic clinical trial

Where it is running

• Cole Eye Institute — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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