Oxidative Stress and Hemodialysis Access Failure

Completed

Conditions studied: End Stage Renal Disease, Hemodialysis

In brief

Complications of hemodialysis access are the most frequent single reason for hospitalization among patients with End Stage Renal Disease (ESRD). Uremia, and particularly uremia in patients with diabetes, is a state of increased oxidative stress. The central hypothesis to be tested by this project is that oxidative stress is a major (and modifiable) trigger for vascular access complications. We hope to slow or reduce rates of stenosis, thrombosis and access complications by giving Vitamin E supplementation to patients being treated by hemodialysis.

Key facts

Study ID

NCT00410449

Run by

National Institute of Environmental Health Sciences (NIEHS)

People needed

35

Starts

2001-05-01

Expected to finish

2004-05-01

Last updated by the study team

2015-10-06

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults, end stage renal disease treated by hemodialysis, patent hemodialysis vascular access (graft or fistula)

You may not qualify if…

• Temporary catheter dialysis access, inability to be compliant with study medication

Where it is running

• Center for Dialysis Care — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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