RAD001 in Previously Treated Patients With Metastatic Pancreatic Cancer

Completed · Phase 2

Conditions studied: Pancreatic Cancer

In brief

The purpose of this research study is to investigate if RAD001 is an effective treatment for pancreatic cancer that has spread and not responded to treatment. Experiments have shown that RAD001 can prevent cells from multiplying. RAD002 has also been tested in laboratory experiments imitating cancer conditions and the results have been promising.

Key facts

Study ID

NCT00409292

Run by

Dana-Farber Cancer Institute

People needed

33

Starts

2007-01-01

Expected to finish

2009-05-01

Last updated by the study team

2014-08-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pathologic confirmation of pancreatic adenocarcinoma
• 18 years of age or older
• At least one measurable site of disease according to RECIST criteria that has not been previously irradiated. If patient has had previous radiation to the marker lesion(s), there must be evidence of progression since the radiation.
• Treated with gemcitabine-based chemotherapy with documented tumor progression on gemcitabine or intolerance to gemcitabine.
• Prior treatment with no more than 1 prior chemotherapy regimen for metastatic disease.
• Minimum of two weeks since any major surgery, completion of radiation, or completion of all prior systemic anti-cancer therapy.
• ECOG performance status 0-1.
• Life expectancy of greater than 12 weeks.
• Adequate bone marrow and liver function.
• Must be able to swallow tablets.

You may not qualify if…

• Prior treatment with an investigational drug within the preceding 4 weeks.
• Prior treatment with an inhibitor of mTOR
• Chronic treatment with systemic steroids or another immunosuppressive agent
• More than one prior chemotherapy treatment for metastatic disease
• Uncontrolled brain or leptomeningeal metastases, including patient who continue to require glucocorticoids for brain or leptomeningeal metastases.
• Other malignancies within the past 3 years except for adequately treated carcinoma of the cervix or basal or squamous cell carcinomas of the skin
• Patients with chronic renal insufficiency
• Other concurrent severe and/or uncontrolled medical disease which could compromise participation in the study.
• Known history of HIV seropositivity
• Impairment of gastrointestinal function or gastrointestinal disease that my significantly alter the absorption of RAD001.
• Active, bleeding diathesis or an oral vitamin K antagonist medication
• Women who are pregnant or breast feeding

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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