Donepezil and Brain Activity Patterns in Those at Risk For Alzheimer's Disease
Completed · Phase 1
Conditions studied: Alzheimer's Disease
In brief
The purpose of the study is to examine patterns of brain activity in people who are at risk for memory problems (e.g., Alzheimer's disease or dementia)before and after the medication donepezil. Although genetic testing will be done, the results will not be shared with study participants. Once the genetic testing is completed subjects may continue to the second phase of the study. During this time they will be asked to take the medication donepezil (which is approved by the FDA for the treatment of Alzheimer's disease). Donepezil is not FDA approved for healthy volunteers and is therefore considered investigational in this study.
Key facts
- Study ID
- NCT00408525
- Run by
- Vanderbilt University
- People needed
- 41
- Starts
- 2006-12-01
- Expected to finish
- 2012-08-24
- Last updated by the study team
- 2018-02-05
Who can join
Age: 40 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Subjects may report experiencing subjective memory dysfunction, however they must be found by clinical evaluation to have no memory dysfunction
- Neuropsychological test battery in the normal range
- Ages 40-85
You may not qualify if…
- Dementia (Mini-Mental State Exam less than 25/30)
- Left-handedness
- Current medication that could influence cognition
- Medical, psychiatric, and neurologic conditions, including cerebrovascular disease or uncontrolled hypertension
- Claustrophobia
- Surgical clips or implants
- Pacemakers or other implanted electronic devices
- History of sheet metal work
Where it is running
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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